Cleft palate discovery in dogs to aid in understanding human birth defect

Discovery of a genetic mutation that causes a form of cleft palate in a retriever breed provides the first dog model for this craniofacial defect and offers a tool for better understanding cleft palate in humans. Although cleft palate is one of the most common birth defects in children, affecting approximately one in 1,500 live human births in the United States, it is not completely understood.